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Sunday, May 10, 2020 | History

2 edition of Incorporation of microspheres into nerve guidance channels for drug delivery purposes. found in the catalog.

Incorporation of microspheres into nerve guidance channels for drug delivery purposes.

Alexandra Piotrowicz

Incorporation of microspheres into nerve guidance channels for drug delivery purposes.

by Alexandra Piotrowicz

  • 380 Want to read
  • 26 Currently reading

Published .
Written in English


About the Edition

Implantation of nerve guidance channels has been shown to be a promising strategy for repair of spinal cord transection injuries; however, regeneration is limited and may be improved by the long-term delivery of therapeutic agents. To enable localized, controlled and sustained delivery of NGF to the lumen of poly(HEMA-co-MMA) channels, NGF-loaded PLGA microspheres were incorporated into a polymer layer on the inside of the channels. Channels loaded with NGF were also prepared by soaking their interior in NGF solution or by entrapping NGF directly in a polymer layer on the inside of the channels. Only low microsphere loadings could be achieved in the channels with microspheres, and as a result of this, and an imperfect microsphere formulation, these channels released limited amounts of NGF in in-vitro release studies. Channels with NGF entrapped directly in the inner layer were able to deliver the largest amount of NGF in a sustained manner.

The Physical Object
Pagination108 leaves.
Number of Pages108
ID Numbers
Open LibraryOL19215569M
ISBN 100494024518

Novel drug delivery system development is largely based on promoting the therapeutic effects of a drug and minimizing its toxic effects by increasing the amount and persistence of a drug in the vicinity of a target cell and reducing the drug exposure of nontarget cells. [18] CLASSIFICATION. There are different types of Microspheres. 1. Glass. in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body. Keywords: Microspheres, extended release, target site, new drug delivery. 1. Introduction An extended drug delivery system can solve some of the problems of .

Principle of magnetic microspheres drug targeting Drug targeting is a specific form of drug delivery where the drug is directed to its site action or absorption. This could be a particular cell, organ structure or tissues. The aim of the specific targeting is to enhance the efficiency of drug delivery and at the. Finally, the drug efficacy of the prepared insulin-loaded microspheres via oral administration was evaluated in rats with diabetes induced by streptozotocin, and an obvious dose-dependent hypoglycemic effect was observed. This preliminary data could illustrate the prospect of using microspheres for the oral delivery of insulin.

A review on microspheres as drug delivery carriers for management of diabetes mellitus B. Rathore*, A. Yadav, G. Nayak, G. K. Saraogi and A. K. Singhai Abstract Diabetes mellitus is a metabolic disorder, characterized by chronic hyperglycemia with disturbances of. Microspheres an innovative approach in drug delivery system Volume 5 Issue 1 - Neeta Solanki Department of Pharmaceutical Sciences, Maharshi Dayanand University, India Correspondence: Neeta Solanki, Department of Pharmaceutical sciences, Maharshi Dayanand University, Rohtak–, Haryana, India, Tel +91–


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Incorporation of microspheres into nerve guidance channels for drug delivery purposes by Alexandra Piotrowicz Download PDF EPUB FB2

Nerve guidance channels (NGCs) have been shown to facilitate regeneration after transection injury to the peripheral nerve or spinal cord.

Various therapeutic molecules, including neurotrophic factors, have improved regeneration and functional recovery after injury when combined with NGCs; however, their impact has not been maximized partly due to the lack of an appropriate drug delivery by: Biomaterials 27 () – Nerve guidance channels as drug delivery vehicles Alexandra Piotrowicza,b, Molly S.

Shoicheta,b,c, aDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, College St., Toronto, Ont., Canada M5S 3E5 bInstitute of Biomaterials and Biomedical Engineering, University of Toronto, 4 Taddle Creek Rd., RoomToronto, Ont., Canada.

Biomaterials. Mar;27(9) Epub Oct Nerve guidance channels as drug delivery vehicles. Piotrowicz A(1), Shoichet MS. Author information: (1)Department of Chemical Engineering and Applied Chemistry, University of Toronto, College St., Toronto, Ont., Canada.

Nerve guidance channels (NGCs) have been shown to facilitate regeneration after transection injury to the Cited by: Although many of these drug delivery strategies are incorporated into a physical scaffold, such as a nerve guidance channel [, ], others may be applied to compression/contusion injury in the.

To physically support the lumen of nerve guidance channels, hydrogels can be added to scaffolds as a filler material within synthetic nerve conduits (Lin and Marra, ). Applying a hydrogel filler to the scaffold would facilitate an easier method to load bioactive agents, stem cells, and growth factors (Tonda-Turo et al., ).

Incorporation of double-walled microspheres into polymer nerve guides for the sustained delivery of glial cell line-derived neurotrophic factor. Kokai LE(1), Ghaznavi AM, Marra KG. Author information: (1)Department of Bioengineering, University of Pittsburgh, Pittsburgh, PAUSA.

usually formulated into microspheres and filling them into hard gelatin capsules. Microspheres received much attention not only for prolonged release, but also for targeting of drugs.

In future microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, genetic materials, targeted and. Nose to brain drug delivery has received a great deal of attention as a non-invasive, convenient and reliable drug delivery system for the systemic and targeted administration of drugs.

Microspheres can be defined as solid, approximately spherical particles ranging in size from 1 to μm. Made up of polymeric, waxy, or other protective materials such as starches, gums, proteins, fats, and waxes and used as drug carrier matrices for drug delivery.

Microcapsules: micrometric reservoir systems Microspheres: micrometric matrix. It is considered as a potential carrier of drug or protiens (for either their site specific localization or their local application into anatomical discrete sites).

It is being widely used for the targeted drug for the targeted drug delivery to the tumour cells. Gelatin7 microspheres can be used as efficient. Indeed, drug delivery systems—designed to provide a therapeutic agent in the needed amount, at the right time, to the proper location in the body, in a manner that optimizes efficacy, increases compliance and minimizes side effects—were responsible for $47 billion in sales inand the drug delivery market is expected to grow to $ DEFINATION: DEFINATION Microspheres can be defined as solid, approximately spherical particles ranging in size from 1 to μ m.

Made up of polymeric, waxy, or other protective materials such as starches, gums, proteins, fats, and waxes and used as drug carrier matrices for drug delivery. Targeting of drug to the particular site is an important aspect of drug delivery system. Carrier technology offers an intelligent approach for drug delivery by coupling the drug to a carrier particle such as microsphere which modulates the release and absorption characteristics of the drug.

These delivery systems offer numerous advantages over. A nerve guidance conduit (also referred to as an artificial nerve conduit or artificial nerve graft, as opposed to an autograft) is an artificial means of guiding axonal regrowth to facilitate nerve regeneration and is one of several clinical treatments for nerve direct suturing of the two stumps of a severed nerve cannot be accomplished without tension, the standard clinical.

(microspheres melt out during firing, polyetheylene) • Cosmetics - Opaque microspheres used to hide wrinkles and give color, Clear microspheres provide "smooth ball bearing" texture during application (polyethylene) • Drug Delivery - Miniture time release drug capsule (polymer) • Electronic paper - Dual Functional microspheres used in Gyricon.

pheres in general, have the potential to be used for targeted and controlled release drug delivery but coupling of mucoadhesive properties to microspheres has additional advantages, e.g. efficient absorption and enhanced bioavailability of the drugs due to a high surface to volume ratio, a much more.

Polymer microspheres delivery systems offer a lot of advantages in chemotherapy where they provided localized sustained release and reduced toxicity at the same time, since the drug can be localized by direct injection of drug-loaded-microspheres into tumor tissue, thus minimizing negative effect to.

ABSTRACT: Microspheres play a very important role as particulate drug delivery system because of their small size and other efficient properties. Microspheres have been proved to be a suitable bridge to scale the distance over to formulate an effective dosage form, to simulate controlled drug release.

Controlled release drug delivery employs drug-encapsulating devices from which therapeutic agents may be released at controlled rates for long periods of time, ranging from days to months. Such systems offer numerous advantages over traditional methods of drug delivery, including tailoring of drug release rates, protection of fragile drugs and.

Charge Microspheres and Microparticles (2) Clinical Studies (1) Coatings (11) Color Microspheres (20) Conductive Microspheres (5) Density Markers (4) DNA Research (3) Drug Delivery (11) FDA-approved Microspheres (2) Fluorescent Microspheres (17) Glass microspheres (14) Magnetic Microspheres (7) Metal Microspheres (9) Microparticles (2.

DEFINITION: DEFINITION Microspheres can be defined as solid, approximately spherical particles ranging in size from 1 to µm. They are made from polymeric, waxy, or other protective materials such as starches, gums, proteins, fats and waxes and used as drug carrier matrices for drug delivery.Microspheres: as carrieres used for novel drug delivery system 45 (ferromagnetic)to be captured in microvessels and dragged into the adjuscent tissues by magnetic field of tesla.

Floating Microspheres(4)(8)(9): Gastro-retentive floating microspheres are low-density systems that have.Scientia Pharmaceutica Review Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery Miléna Lengyel 1, Nikolett Kállai-Szabó 1, Vince Antal 1, András József Laki 2,3 and István Antal 1,* 1 Department of Pharmaceutics, Semmelweis University, Hogyes˝ E.

str 7, Budapest, Hungary 2 Pázmány Péter Catholic University, Faculty of Information Technology and Bionics.